期刊
PROGRESS IN POLYMER SCIENCE
卷 39, 期 9, 页码 1585-1613出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2014.05.001
关键词
Biomaterial; Stem cell; Thixotropic; Photoresponsive; Thermoresponsive; Microcarrier
资金
- National Science Council of Taiwan [101-2120-M-008-003, 102-2120-M-008-002, 102-2221-E-008-112-MY2]
- LandSeed Hospital project [NCU-LSH-101-A-001, NCU-LSH-102-A-003]
- National Defense Medical Center Project [102NCU-NDMC-01]
- Cathay General Hospital Project [101CGH-NCU-A2, 102NCU-CGH-02, CGH-MR-10025, CGH-MR-10103, CGH-MR-10115, CGH-MR-A10204]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [24560968]
- International High Cited Research Group (IHCRG) [14-104]
- Deanship of Scientific Research, King Saud University, Riyadh, Kingdom of Saudi Arabia
- Grants-in-Aid for Scientific Research [24560968] Funding Source: KAKEN
The physical and chemical characteristics of biomaterial surface and hydrogels can be altered by external stimuli, such as light irradiation, temperature changes, pH shifts, shear stress forces, electrical forces, and the addition of small chemical molecules. Such external stimulus-responsive biomaterials represent promising candidates that have been developed for the culture and differentiation of embryonic stem (ES) cells, induced pluripotent stem (iPS) cells, and adult stem cells. Biomaterials that are designed to respond in a reversible manner to specific external signals can be formed on micropatterned or non-micropatterned surface, in hydrogels, or on microcarriers. Stem cells and the cells differentiated from them into specific tissue lineages can be cultured and/or differentiated on dishes with immobilized external stimulus-responsive polymers. Cells can be detached from these dishes without using an enzymatic digestion method or a mechanical method when the appropriate external stimulus is generated on the surface. This review discusses the polymers and polymeric designs employed to produce surface and hydrogels for stem cell culture, differentiation, and/or cell detachment using various external stimuli. (C) 2014 Elsevier Ltd. All rights reserved.
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