期刊
PROGRESS IN POLYMER SCIENCE
卷 37, 期 1, 页码 18-37出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2011.08.001
关键词
Atom Transfer Radical Polymerization (ATRP); Drug delivery; Biomedical engineering; Biomaterials; Imaging; Nanoparticles; Nanogels; Tissue engineering; Bioconjugation; Polymeric micelles; Polymer grafting; Functionality; Block copolymers; Bioactive surfaces
资金
- Ruth L. Kirschstein National Research Service Award (NRSA)
- National Institute of Biomedical Imaging and Bioengineering (NIBIB) [F32EB011867]
- NSERC Canada
- NSERC CRC
- Concordia University
- NSF [DMR-09-69301]
- Korea Science and Engineering Foundation
- Ministry of Education, Science and Technology [R33-10035-0]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [F32EB011867] Funding Source: NIH RePORTER
Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications. (C) 2011 Elsevier Ltd. All rights reserved.
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