期刊
PROGRESS IN POLYMER SCIENCE
卷 36, 期 9, 页码 1099-1131出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2010.11.005
关键词
Gene delivery; Polymeric carriers; LRP; ATRP; RAFT
资金
- National Natural Science Foundation of China [21074007]
- Higher Education of China [20090010120007]
- Program for New Century Excellent Talents in University [NCET-10-0203]
- Fundamental Research Funds for the Central Universities [ZZ0904]
- Fok Ying Tung Education Foundation [121048]
- SRF for ROCS, SEM
The design of efficient gene delivery vectors is a challenging task in gene therapy. Recent progress in living/controlled radical polymerizations (LRPs), in particular atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization providing a means for the design and synthesis of new polymeric gene vectors with well-defined compositions, architectures and functionalities is reviewed here. Polymeric gene vectors with different architectures, including homopolymers, block copolymers, graft copolymers, and star-shaped polymers, are conveniently prepared via ATRP and RAFT polymerization. The corresponding synthesis strategies are described in detail. The recent research activities indicate that ATRP and RAFT polymerization have become essential tools for the design and synthesis of advanced, noble and novel gene carriers. (C) 2011 Elsevier Ltd. All rights reserved.
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