期刊
PROGRESS IN POLYMER SCIENCE
卷 35, 期 1-2, 页码 252-277出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2009.10.007
关键词
Biopolymer; Hybrid device; Kinesin; Myosin; Microtubule; Actin; Molecular shuttle; Molecular motor; Motor protein; Cyotskeletal filament
资金
- NSF [DMR-0645023]
The dynamic cytoskeletal components, biomolecular motors and their associated filaments, can be integrated in vitro with synthetic components to enable nanoscale transport Systems. These molecular shuttles have generated significant scientific interest over the past decade, resulting in over 200 publications. This review focuses on the contributions involving the use of linear biomolecular Motors, kinesin and myosin, and their associated filaments, microtubule and actin, in device applications. Exploiting the naturally occurring motion between the motors and their associated filaments requires an interdisciplinary understanding of the underlying challenges. Three basic topics that most of the experimental contributions have sought to address are: the guiding of shuttle movement, the loading and unloading of cargo onto the shuttles, and the control of motor activity. The physical properties of motors and filaments determine the engineering solutions to the design challenges. The applications, which center on the basic capability of nanoscale motion, and the roadblocks to their widespread implementation will be discussed in detail. (C) 2009 Elsevier Ltd. All rights reserved.
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