期刊
PROGRESS IN POLYMER SCIENCE
卷 34, 期 9, 页码 893-910出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2009.05.002
关键词
Thermo-sensitive; Micelle; Poly(N-isopropylacrylamide); Self-assembly; Drug delivery
资金
- National Key Basic Research Program of China [2005CB623903]
- National Natural Science Foundation of China [50633020]
- Ministry of Education of China [707043]
Amphiphilic copolymers are well developed as precursors for the preparation of micellar drug carriers. Poly(N-isopropylacrylamide) (PNIPAAm) is one of the most extensively studied thermo-sensitive polymers that exhibits a lower critical solution temperature (LCST) at around 33 degrees C in aqueous solution. Over the past decade, considerable efforts have been devoted to design and preparation of PNIPAAm-based thermo-sensitive polymeric micelles as delivery vehicles for controlled drug release. Present review highlights the recent developments in this field, and focuses on two categories of PNIPAAm-based copolymer micelles as smart drug delivery systems, i.e. micelles with PNIPAAm as hydrophilic shell-forming segments below the LCST and micelles with PNIPAAm as hydrophobic core-forming segments above the LCST. (C) 2009 Elsevier Ltd. All rights reserved.
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