期刊
NATURE COMMUNICATIONS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms7606
关键词
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资金
- National Institutes of Health (NIH) [R01AG032383, R01NS076775, R01NS038572, K02AG041815, R01NS081203, R01DA016765, K02DA023555]
- National Aeronautics and Atmospheric Association (NASA) [NX12AB55G]
- American Heart Association training grant [5T32HL007360-34]
- NIH predoctoral training grant [5T32GM083831-05]
- Texas Institute for Brain Injury and Repair at UT Southwestern
- Welch Foundation [I-1660]
- Haggerty Center for Brain Injury and Repair
Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult-generated neurons in the development of chronic seizures or associated cognitive deficits remains to be determined. Here we show that the ablation of adult neurogenesis before pilocarpine-induced acute seizures in mice leads to a reduction in chronic seizure frequency. We also show that ablation of neurogenesis normalizes epilepsy-associated cognitive deficits. Remarkably, the effect of ablating adult neurogenesis before acute seizures is long lasting as it suppresses chronic seizure frequency for nearly 1 year. These findings establish a key role of neurogenesis in chronic seizure development and associated memory impairment and suggest that targeting aberrant hippocampal neurogenesis may reduce recurrent seizures and restore cognitive function following a pro-epileptic brain insult.
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