期刊
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
卷 83, 期 -, 页码 42-49出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnmrs.2014.09.001
关键词
NMR; Metabolomics; Metabolic profiling; Nutrition
资金
- FP7 Project NutriTech [289511]
- Department of Agriculture Fisheries and Food under the Food for Health Research Initiative [7FHRIUCC2]
Metabolomics is the study of metabolites present in biological samples such as biofluids, tissue/cellular extracts and culture media. Measurement of these metabolites is achieved through use of analytical techniques such as NMR and mass spectrometry coupled to liquid chromatography. Combining metabolomic data with multivariate data analysis tools allows the elucidation of alterations in metabolic pathways under different physiological conditions. Applications of NMR-based metabolomics have grown in recent years and it is now widely used across a number of disciplines. The present review gives an overview of the developments in the key steps involved in an NMR-based metabolomics study. Furthermore, there will be a particular emphasis on the use of NMR-based metabolomics in nutrition research. (C) 2014 Elsevier B.V. All rights reserved.
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