期刊
PROGRESS IN NEUROBIOLOGY
卷 105, 期 -, 页码 24-48出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2013.03.002
关键词
Neuronal death; Apoptosis; Necrosis; Autophagy; Stroke; Hypoxia-ischemia
资金
- Swiss National Science Foundation [310030-130769]
- Faculty of Biology and Medicine of the University of Lausanne
- Swiss National Science Foundation (SNF) [310030_130769] Funding Source: Swiss National Science Foundation (SNF)
There is currently no approved neuroprotective pharmacotherapy for acute conditions such as stroke and cerebral asphyxia. One of the reasons for this may be the multiplicity of cell death mechanisms, because inhibition of a particular mechanism leaves the brain vulnerable to alternative ones. It is therefore essential to understand the different cell death mechanisms and their interactions. We here review the multiple signaling pathways underlying each of the three main morphological types of cell death - apoptosis, autophagic cell death and necrosis - emphasizing their importance in the neuronal death that occurs during cerebral ischemia and hypoxia-ischemia, and we analyze the interactions between the different mechanisms. Finally, we discuss the implications of the multiplicity of cell death mechanisms for the design of neuroprotective strategies. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据