期刊
PROGRESS IN NEUROBIOLOGY
卷 96, 期 3, 页码 304-321出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2012.01.009
关键词
Presynaptic regulation; Exocytosis; SNARE proteins; Heterotrimeric G proteins
资金
- National Institute of Health [R01 EY010291]
Synaptic transmission is a finely regulated mechanism of neuronal communication. The release of neurotransmitter at the synapse is not only the reflection of membrane depolarization events, but rather, is the summation of interactions between ion channels, G protein coupled receptors, second messengers, and the exocytotic machinery itself which exposes the components within a synaptic vesicle to the synaptic cleft. The focus of this review is to explore the role of G protein signaling as it relates to neurotransmission, as well as to discuss the recently determined inhibitory mechanism of G beta gamma dimers acting directly on the exocytotic machinery proteins to inhibit neurotransmitter release. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据