期刊
PROGRESS IN NEUROBIOLOGY
卷 92, 期 2, 页码 184-211出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2010.05.002
关键词
Heat shock protein; Synaptic transmission; Protein degradation; Cell death; Cerebral ischemia; Parkinson's disease; Huntington's disease; Alzheimer's disease; Prion; Charcot-Marie-Tooth
资金
- American Heart Association [09POST22006065]
- National Institutes of Health [NS36736, NS43802, NS45048]
- VA Merit Review Grant
- Chinese National Science Foundation [30870794, 30670642]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS045048, R01NS036736, P01NS059806, R01NS056118, R01NS043802] Funding Source: NIH RePORTER
Emerging evidence indicates that heat shock proteins (HSPs) are critical regulators in normal neural physiological function as well as in cell stress responses. The functions of HSPs represent an enormous and diverse range of cellular activities, far beyond the originally identified roles in protein folding and chaperoning. HSPs are now understood to be involved in processes such as synaptic transmission, autophagy, ER stress response, protein kinase and cell death signaling. In addition, manipulation of HSPs has robust effects on the fate of cells in neurological injury and disease states. The ongoing exploration of multiple HSP superfamilies has underscored the pluripotent nature of HSPs in the cellular context, and has demanded the recent revamping of the nomenclature referring to these families to reflect a re-organization based on structure and function. In keeping with this re-organization, we first discuss the HSP superfamilies in terms of protein structure, regulation, expression and distribution in the brain. We then explore major cellular functions of HSPs that are relevant to neural physiological states, and from there we discuss known and proposed HSP impacts on major neurological disease states. This review article presents a three-part discussion on the array of HSP families relevant to neuronal tissue, their cellular functions, and the exploration of therapeutic targets of these proteins in the context of neurological diseases. Published by Elsevier Ltd.
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