期刊
PROGRESS IN NEUROBIOLOGY
卷 85, 期 2, 页码 135-147出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2008.03.003
关键词
nicotine; ethanol; Parkinson's disease; therapeutic stratergies
In this short review, neurochemical targets are identified where nicotine, and possibly ethanol, may interact to prevent the occurrence of Parkinson's disease. These are (a) the nicotinic acetycholine receptors present in the nigrostriatal area or on the surface of microglia, (b) monoamine oxidases and (c) inducible nitric oxide synthase. If such induced changes can be verified in clinical studies, this may help in the design of new therapeutic drugs which may be of relevance to diminish the incidence and perhaps the progression of the debilitating condition of Parkinson's disease. (C) 2008 Elsevier Ltd. All rights reserved.
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