4.6 Article

Heterogeneity of elderly depression: Increased risk of Alzheimer's disease and Aβ protein metabolism

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2012.12.016

关键词

Amyloid; Depression; Early onset; Elderly; Late onset; Serum

资金

  1. Research Support Foundation of the Juntendo Institute of Mental Health

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Epidemiological studies have proposed that depression may increase the risk for Alzheimer's disease (AD), even in patients with early-onset depression. Although metabolism of amyloid beta protein (A beta) in elderly depression received attention in terms of their correlation, there is a serious heterogeneity in elderly depression in terms of age at onset of depression. Moreover, it is unknown whether early-onset major depressive disorder (MDD) has a long-term effect on the involvement of A beta metabolism and later development of AD. Thus, we evaluated serum A beta 40 and A beta 42 levels, the A beta 40/A beta 42 ratio in 89 elderly (>= 60 years of age) inpatients with MDD and 81 age-matched healthy controls, and compared them among patients with early-onset (<60 years) and late-onset (>= 60 years) MDD and controls. The results showed that the serum A beta 40/A beta 42 ratio was significantly higher in patients with both early- and late-onset MOD than in controls (early-onset, p = 0.010; late-onset, p = 0.043), and it is of great interest that the serum A beta 40/A beta 42 ratio was negatively correlated with the age at MDD onset (R = -0.201, p = 0.032). These results suggest that an earlier onset of MDD may have a more serious abnormality in A beta metabolism, possibly explaining a biological mechanism underlying the link between depression and AD. (C) 2012 Elsevier Inc. All rights reserved.

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