期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 34, 期 7, 页码 1223-1228出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2010.06.024
关键词
Antidepressant; Dietary flavonoid; Naringenin; Noradrenaline; Serotonin
资金
- Scientific Research Administration Department of Huaqiao University [09BS507]
Dietary flavonoids possess a multiplicity of neuroprotective actions in various central nervous pathophysiological conditions including depression In this study, the neuropharmacological mechanism of the dietary flavonoid naringenin was investigated in the mouse behavioral models of depression For this purpose, we investigated the influence of pretreatment with the inhibitors of serotonin or noradrenaline synthesis. p-chlorophenylalanine methyl ester or a-methyl-p-tyrosine. respectively in the anti-immobility effect of naringenin Compared to the control group, naringenin significantly decreased the immobility time after acute treatment in the mouse tail suspension test (10. 20 and 50 mg/kg), but not in the forced swimming test, without producing locomotor alteration in the open-field test In addition, pretreatment of mice with p-chlorophenylalanine methyl ester (100 mg/kg) or a-methyl-p-tyrosine (100 mg/kg) prevented the anti-immobility effect of naringenin (20 mg/kg) in the tail suspension test Taken together, this data demonstrated that naringenin possessed potent antidepressant-like property via the central serotonergic and noradrenergic systems Thus, our findings suggest the therapeutic potential of this dietary flavonoid in central nervous system disorders especially depression where monoaminergic systems are involved (C) 2010 Elsevier Inc All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据