期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 32, 期 7, 页码 1633-1636出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2008.06.007
关键词
case-control study; neural cell adhesion molecule 1; schizophrenia; SNP
资金
- Chinese Ministry of Education [10414]
- national 973 and 863 programs of China [2006AA02A407]
- National Natural Science Foundation of China
- Shanghai Municipal Commission for Science and Technology
- Shanghai Leading Academic Discipline Project [13205]
Background: The neural cell adhesion molecule 1(NCAM1, aliases NCAM and CD56) is a cell-surface molecule which makes homophilic adhesion between neural cells involved in cell migration, axon outgrowth and synaptic plasticity. Recent studies reported that NCAM1 might act as a candidate schizophrenia susceptibility gene. Method: We genotyped five SNPs (rs1943620, rs1836796, rs1821693, rs686050, rs584427) within the NCAM1 gene and conducted a case-control study in 288 schizophrenic patients and 288 healthy subjects in the Chinese Han population. We compared allele and genotype frequencies and haplotype distributions between cases and controls. Result: No significant differences in allele and genotype frequencies were found for each single SNP between schizophrenic patients and healthy subjects. Moreover, there were no significant differences in haplotype distributions between cases and controls (global chi(2) = 1.318, P=0.725, df=3). Conclusion: Our study suggests that the five SNPs within NCAM1 gene we studied may not play a major role in the schizophrenia susceptibility in the Chinese Han population. (c) 2008 Published by Elsevier Inc.
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