期刊
PROGRESS IN LIPID RESEARCH
卷 72, 期 -, 页码 42-54出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2018.09.001
关键词
Stem cells; Lysophosphatidic acid; Sphingosine-1-phosphate
资金
- Australian Research Council [FT140100047]
- National Health and Medical Research Council [1042589, 430907]
- CERA Foundation
- Fay Fuller Foundation
- Neurosurgical Research Foundation
- University of Melbourne
- Stem Cells Australia - the Australian Research Council Special Research Initiative in Stem Cell Science
Stem cells are unique in their ability to self-renew and differentiate into various cell types. Because of these features, stem cells are key to the formation of organisms and play fundamental roles in tissue regeneration and repair. Mechanisms controlling their fate are thus fundamental to the development and homeostasis of tissues and organs. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive phospholipids that play a wide range of roles in multiple cell types, during developmental and pathophysiological events. Considerable evidence now demonstrates the potent roles of LPA and SW in the biology of pluripotent and adult stem cells, from maintenance to repair. Here we review their roles for each main category of stem cells and explore how those effects impact development and physiopathology.
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