期刊
PROGRESS IN LIPID RESEARCH
卷 55, 期 -, 页码 1-16出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2014.04.001
关键词
Cardiolipin; Disease; Fatty acids; Membranes; Mitochondria; Phospholipids
资金
- Barth Syndrome Foundation
- National Institutes of Health
- United Mitochondrial Disease Foundation
- American Heart Association
Since it has been recognized that mitochondria are crucial not only for energy metabolism but also for other cellular functions, there has been a growing interest in cardiolipin, the specific phospholipid of mitochondrial membranes. Indeed, cardiolipin is a universal component of mitochondria in all eukaryotes. It has a unique dimeric structure comprised of two phosphatidic acid residues linked by a glycerol bridge, which gives rise to unique physicochemical properties. Cardiolipin plays an important role in the structural organization and the function of mitochondrial membranes. In this article, we review the literature on cardiolipin biology, focusing on the most important discoveries of the past decade. Specifically, we describe the formation, the migration, and the degradation of cardiolipin and we discuss how cardiolipin affects mitochondrial function. We also give an overview of the various phenotypes of cardiolipin deficiency in different organisms. (C) 2014 Elsevier Ltd. All rights reserved.
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