期刊
PROGRESS IN LIPID RESEARCH
卷 51, 期 3, 页码 232-237出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2012.02.003
关键词
Omega-3; PPAR gamma; GPR120; Resolvin; Fish oil; GPCR
资金
- MRC of the National Research Foundation of Korea [2009-0083538]
- Korea government (MEST)
- National Research Foundation of Korea [2009-0093226] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Omega-3 fatty acids, such as, DNA and EPA, have well established beneficial effects on human health, but their action mechanisms remain unknown. Recent pharmacological studies have suggested several molecular targets for the anti-inflammatory effects of omega-3 fatty acids, namely, nuclear receptor PPAR gamma and the G protein-coupled receptor GPR120. Furthermore, the conversions of omega-3 fatty acids to anti-inflammatory and pro-resolving resolvins and protectins and the identifications of putative target GPCRs, ChemR23, BLT1, ALX/FPR2, and GPR32, have drawn great attention. In addition, the pharmacology of omega-3 fatty acids is now under scrutiny. However, questions remain to be answered regarding the in vivo effects of omega-3 fatty acids at the molecular level. In this review, anti-inflammatory effects of omega-3 fatty acids are discussed from the viewpoint of molecular pharmacology, particularly with respect to the above-mentioned GPCRs. (C) 2012 Elsevier Ltd. All rights reserved.
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