期刊
PROGRESS IN LIPID RESEARCH
卷 49, 期 4, 页码 378-389出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2010.05.001
关键词
Membrane domains; Equilibrium thermodynamic phases; Non equilibrium phenomena; Trans-bilayer structure; Lateral pressure profile; Biological membrane model
资金
- Danish National Research Foundation
- Forskningsradet for Natur og Univers (FNU, Denmark)
- Forskningsradet for Sundhed og Sygdom (FSS, Denmark)
Lipid-bilayer membranes are formed by self-assembly processes. The molecular interactions within the bilayer and with the environment impart a unique trans-bilayer lateral pressure profile and provide a set of physical mechanisms for formation of lipid domains and laterally differentiated regions in the plane of the membrane. Results from a number of experimental and theoretical studies of model lipid bilayers are reviewed, emphasizing the significance of these fundamental physical properties for the structure and dynamics of biological membranes. Particular attention is paid to the relevance of postulating the existence of equilibrium thermodynamic phases in biological membranes. This includes a discussion of the possible significance of equilibrium critical points in biological membrane systems that normally exist under non-equilibrium conditions. The need for a new model to replace the celebrated Nicolson-Singer fluid-mosaic model of biological membranes is also discussed. (C) 2010 Elsevier Ltd. All rights reserved.
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