期刊
NATURE COMMUNICATIONS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms6862
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资金
- Wellcome Trust Research Career Development Fellowship
- MRC [MR/K021095/1]
- MRC CASE studentship
- Wellcome Trust
- US National Institutes of Health [DP5OD012116]
- Crohn's and Colitis Foundation of America (CCFA) [297365]
- UCB Celltech
- MRC [G9818340] Funding Source: UKRI
- Medical Research Council [G9818340, MR/K021095/1] Funding Source: researchfish
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP5OD012116] Funding Source: NIH RePORTER
Presentation of peptide: MHCII by ROR gamma-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.
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