期刊
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
卷 103, 期 1, 页码 2-17出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2009.10.002
关键词
Transient receptor potential; Ca2+ channels; Vanilloid receptor; Mechanosensor; Bladder; Bone diseases
资金
- Belgian Federal Government [IUAP P5/05]
- Research Foundation-Flanders [G.0172.03, G.0149.03, G.0565.07, G.0686.09]
- Astellas European Foundation
- Research Council of the KU Leuven [EF/95/010]
The Transient Receptor Potential Vanilloid 4 channel, TRPV4, is a Ca2+ and Mg2+ permeable non-selective cation channel involved in many different cellular functions. It is activated by a variety of physical and chemical stimuli, including heat, mechano-stimuli, endogenous substances such as arachidonic acid and its cytochrome P450-derived metabolites (epoxyeicosatrienoic acids), endocannabinoids (anandamide and 2-arachidonoylglycerol), as well as synthetic a-phorbol derivatives. Recently, TRPV4 has been characterized as an important player modulating osteoclast differentiation in bone remodelling and as a urothelial mechanosensor that controls normal voiding. Several TRPV4 gain-of-function mutations are shown to cause autosomal-dominant bone dysplasias such as brachyolmia and Koszlowski disease. In this review we comprehensively describe the structural, biophysical and (patho)physiological properties of the TRPV4 channel and we summarize the current knowledge about the role of TRPV4 in the pathogenesis of several diseases. (C) 2009 Elsevier Ltd. All rights reserved.
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