期刊
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
卷 39, 期 12, 页码 1133-1144出版社
CHINESE ACAD SCIENCES, INST BIOPHYSICS
DOI: 10.3724/SP.J.1206.2012.00015
关键词
TP53 gene; miRNAs; signaling pathway; tumor; transcription
资金
- National Natural Science Foundation of China [30871282, 30871365, 30971147, 81172189, 81171930, 81272298]
- Hunan Province Natural Science Foundation of China [10JJ7003]
- Fok Ying Tong Education Foundation [121036]
- Fundamental Research Funds for The Central Universities [2011JQ020]
- Mittal Innovative Entrepreneurial Project of Central South University [11MX27]
- Open-End Fund for The Valuable and Precision Instruments of Central South University
- Postdoctoral Science Foundation of Central South University
The tumor suppressor TP53 gene, which encodes p53 protein, is a hotspot of all time in molecular oncology. p53 suppresses tumor initiation and progression through its regulation of many downstream genes. Recent studies have revealed that microRNAs (miRNAs) interact with the p53 pathway and form a complex regulatory network. On one hand, p53 promotes cell cycle arrest and induces cell apoptosis and senescence to suppress tumorigenesis by regulating the transcription and post-transcriptional maturation of multiple miRNAs. On the other hand, many miRNAs fine-tune the p53 pathway through regulation of TP53 and its upstream regulators or downstream effectors. The miR-34s family, directly transactivated by p53 represents a large number of p53-regulated miRNAs. They exert their tumor suppressing function via targeted inhibition of multiple key molecules in the p53 pathway. Furthermore, miR-34s enhance p53 activity through a feedback loop by inhibiting silent information regulator 1 (SIRT 1). Investigation on the interaction between miRNAs and p53 is essential to fully understand the underline mechanisms of p53 tumor suppressing action.
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