期刊
NATURE COMMUNICATIONS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms8288
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资金
- Johns Hopkins University School of Medicine Microscope Facility [RR026445]
- National Eye Institute [EY08117, EY10852]
- National Institute of Neurological Disorders and Stroke [NS064684]
Motor coordination is broadly divided into gross and fine motor control, both of which depend on proprioceptive organs. However, the channels that function specifically in fine motor control are unknown. Here we show that mutations in trp gamma disrupt fine motor control while leaving gross motor proficiency intact. The mutants are unable to coordinate precise leg movements during walking, and are ineffective in traversing large gaps due to an inability in making subtle postural adaptations that are requisite for this task. TRP gamma is expressed in proprioceptive organs, and is required in both neurons and glia for gap crossing. We expressed TRPg in vitro, and found that its activity is promoted by membrane stretch. A mutation eliminating the Na+/Ca2+ exchanger suppresses the gap-crossing phenotype of trpg flies. Our findings indicate that TRPg contributes to fine motor control through mechanical activation in proprioceptive organs, thereby promoting Ca2+ influx, which is required for function.
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