期刊
PROCESS BIOCHEMISTRY
卷 46, 期 2, 页码 482-488出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.procbio.2010.09.022
关键词
Physalis angulata L.; Solanaceae; Withangulatin A; Immunosuppression; HO-1; MAPK; NF-kappa B
资金
- Ministry of Education of China [B07023]
- Shanghai Leading Academic Discipline Project [B507]
Withangulatin A (WA), a bioactive withanolide isolated from Physalis angulata L, has a strong immunosuppressive activity. We have demonstrated that WA significantly suppressed the over-proliferation of ConA-induced T lymphocytes in a dose- and time-dependent manner, which modulated Th1/Th2-type balance dramatically. Moreover, WA-induced heme oxygenase 1 (HO-1) expression in mice T lymphocytes through the ERK/MAPK pathway and inhibited ConA-induced nuclear factor kappa B (NF-kappa B p65) nuclear translocation, directly or indirectly mediated by HO-1. Notably, WA affected the expression of COX-2 and PPAR-gamma in ConA-induced T lymphocytes. The synergistic manner in which WA enhanced HO-1 expression through the ERK/MAPK pathway and NF-kappa B nuclear translocation and other regulatory proteins, thereby restricting T lymphocytes from over-expression and modulating Th1/Th2-type balance, could be the mechanism for the immunosuppressive properties of WA, the immunosuppressive effect of which may protect against autoimmune disorder diseases. (C) 2010 Elsevier Ltd. All rights reserved.
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