期刊
PROCESS BIOCHEMISTRY
卷 43, 期 8, 页码 829-834出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.procbio.2008.03.005
关键词
Fomitopsis pinicola; polysaccharides; nucleoside; endothelial cell; angiogenesis; inflammation
资金
- National Science Council [NSC95-2313-B-077-001, NSC94-2320-B-077-011]
- National Research Institute of Chinese Medicine, Taiwan
Fomitopsis pinicola is used as a medicinal fungus in Asia. Polysaccharides extracted from 35-day-cultured fungus and its ethanolic extract showed no toxicity to endothelial cells (ECs). Extracted polysaccharides had a strong inhibitory effect on vascular endothelial growth factor (VEGF)-induced tube formation in ECs in a dose-dependent manner. Furthermore, the ethanolic extract dose-dependently suppressed production of the interferon (IFN)-gamma-induced inflammation marker, IP-10. High-molecular-weight of 5367 and 1056 kDa accounted for 19.6% and 19.3% of the total polysaccharides, and a low-molecular-weight one of 14.7 kDa accounted for 53.6% of the total polysaccharides. Chemical analyses of the polysaccharides revealed that myo-inositol, fucose, galactose, glucose, mannose, and fructose were neutral sugars in the polysaccharide. Six nucleoside-type compounds including cytidine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine, inosine, and thymidine were identified in the ethanolic extract. These results suggest that different extracts from F pinicola play different roles in regulating the angiogenic process and inflammation. (C) 2008 Elsevier Ltd. All rights reserved.
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