期刊
NATURE COMMUNICATIONS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms7820
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资金
- ERC Advanced Investigator Grant [294293]
- US National Institutes of Health [DA-23082, DK-32948]
- Natural Science Foundation of China (NSFC) [31171065, 31471059]
- National Basic Research Program (973 Program) [2014CB543200]
- Program for Shaanxi Province Key Research Team of Science and Technology Innovation [2012 KCT-14]
- European Research Council (ERC) [294293] Funding Source: European Research Council (ERC)
Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity-dependent synaptic long-term potentiation as well as activity-dependent remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and structural plasticity during the course of inflammatory pain.
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