期刊
NATURE COMMUNICATIONS
卷 6, 期 -, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/ncomms8208
关键词
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资金
- European Community [HEALTH-F4-2007-201413]
- Helmholtz Zentrum Munchen-German Research Center for Environmental Health
- German Federal Ministry of Education and Research (BMBF)
- State of Bavaria
- Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
- German National Genome Research Network (NGFN
- NGFNPlus) [01GS0834]
- Biomedical Research Program funds at the Weill Cornell Medical College in Qatar - Qatar Foundation
- Estonian Government [IUT20-60, IUT24-6]
- Estonian Research Roadmap through the Estonian Ministry of Education and Research [3.2.0304.11-0312]
- Center of Excellence in Genomics (EXCEGEN)
- Development Fund from the University of Tartu [SP1GVARENG]
- EFSD New Horizons grant
- US National Institute of Health [R01DK075787]
- National Institute for Health Research (NIHR) Clinical Research Facility at Guy's & St Thomas' NHS Foundation Trust
- NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
- King's College London
- Netherlands Organization for Scientific Research (NWO: MagW/ZonMW grants) [904-61-090, 985-10-002, 904-61-193, 480-04-004, 400-05-717, Middelgroot-911-09-032, 56-464-14192]
- Center for Medical Systems Biology (CMSB)
- Netherlands Bioinformatics Centre/BioAssist/RK [2008.024]
- Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)-NL [184.021.007]
- European Science Council [ERC-230374]
- EMGO+ Fellowship
- SURF Foundation
- NWO
- Erasmus MC
- CMSB
- NHMRC-European Union Collaborative Research Grant [496739]
- National Institute for Health Research [NF-SI-0611-10099] Funding Source: researchfish
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome-and metabolome-wide significant (Z-test, P<1.09 x 10(-9)) associations between single-nucleotide polymorphisms (SNPs) and metabolites, involving 59 independent SNPs and 85 metabolites. Five of the fifty-nine independent SNPs are new for serum metabolite levels, and were followed-up for replication in an independent sample (N = 1,182). The novel SNPs are located in or near genes encoding metabolite transporter proteins or enzymes (SLC22A16, ARG1, AGPS and ACSL1) that have demonstrated biomedical or pharmaceutical importance. The further characterization of genetic influences on metabolic phenotypes is important for progress in biological and medical research.
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