期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 281, 期 1782, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rspb.2013.3151
关键词
ageing; stress; telomere; senescence; lifespan; Phalacrocorax aristotelis
资金
- Leverhulme Trust
- European Research Council Advanced Investigator Award
- NSF IRFP [0852962]
- Marie Curie Intra European Fellowship [PIEF-GA-2011-301093]
- Natural Environment Research Council [CEH010021] Funding Source: researchfish
- Office Of Internatl Science &Engineering
- Office Of The Director [0852962] Funding Source: National Science Foundation
Exposure to stressors early in life is associated with faster ageing and reduced longevity. One important mechanism that could underlie these late life effects is increased telomere loss. Telomere length in early post-natal life is an important predictor of subsequent lifespan, but the factors underpinning its variability are poorly understood. Recent human studies have linked stress exposure to increased telomere loss. These studies have of necessity been non-experimental and are consequently subjected to several confounding factors; also, being based on leucocyte populations, where cell composition is variable and some telomere restoration can occur, the extent to which these effects extend beyond the immune system has been questioned. In this study, we experimentally manipulated stress exposure early in post-natal life in nestling European shags (Phalacrocorax aristotelis) in the wild and examined the effect on telomere length in erythrocytes. Our results show that greater stress exposure during early post-natal life increases telomere loss at this life-history stage, and that such an effect is not confined to immune cells. The delayed effects of increased telomere attrition in early life could therefore give rise to a 'time bomb' that reduces longevity in the absence of any obvious phenotypic consequences early in life.
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