期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 281, 期 1794, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rspb.2014.0566
关键词
drug resistance; evolution; treatment strategies
资金
- RAPIDD program of the Science and Technology Directorate, Department of Homeland Security
- Fogarty International Center, National Institutes of Health
- Science and Technology Directorate, Department of Homeland Security [HSHQDC-12-C-00058]
- Medical Research Council [MR/K010174/1, MR/K010174/1B] Funding Source: researchfish
- MRC [MR/K010174/1] Funding Source: UKRI
The evolution of resistance to antimicrobial chemotherapy is a major and growing cause of human mortality and morbidity. Comparatively little attention has been paid to how different patient treatment strategies shape the evolution of resistance. In particular, it is not clear whether treating individual patients aggressively with high drug dosages and long treatment durations, or moderately with low dosages and short durations can better prevent the evolution and spread of drug resistance. Here, we summarize the very limited available empirical evidence across different pathogens and provide a conceptual framework describing the information required to effectively manage drug pressure to minimize resistance evolution.
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