期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 280, 期 1757, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rspb.2013.0007
关键词
mutator; Pseudomonas aeruginosa; oxidative stress; evolution; trade-off
资金
- Spanish Government (MEC Fellowship)
- Royal Society
- European Research council
- NERC (UK)
- Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III
- European Development Regional Fund 'A way to achieve Europe' ERDF, through the Spanish Network for Research in Infectious Diseases [REIPI RD06/0008]
The dominant paradigm for the evolution of mutator alleles in bacterial populations is that they spread by indirect selection for linked beneficial mutations when bacteria are poorly adapted. In this paper, we challenge the ubiquity of this paradigm by demonstrating that a clinically important stressor, hydrogen peroxide, generates direct selection for an elevated mutation rate in the pathogenic bacterium Pseudomonas aeruginosa as a consequence of a trade-off between the fidelity of DNA repair and hydrogen peroxide resistance. We demonstrate that the biochemical mechanism underlying this trade-off in the case of mutS is the elevated secretion of catalase by the mutator strain. Our results provide, to our knowledge, the first experimental evidence that direct selection can favour mutator alleles in bacterial populations, and pave the way for future studies to understand how mutation and DNA repair are linked to stress responses and how this affects the evolution of bacterial mutation rates.
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