期刊
PROCEEDINGS OF THE NUTRITION SOCIETY
卷 71, 期 1, 页码 154-165出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0029665111003338
关键词
DNA methylation; C-1 metabolism; DOHaD; Methyl donors
资金
- Wellcome Trust [WT086369MA]
- Medical Research Council [MC_U123292701, MC_U123292700] Funding Source: researchfish
- MRC [MC_U123292701, MC_U123292700] Funding Source: UKRI
Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA methylation, play a role in these processes. This paper reviews the current state of knowledge of the involvement of C-1 metabolism and methyl donors and cofactors in maternal diet-induced DNA methylation changes in utero as an epigenetic mechanism. Methyl groups for DNA methylation are mostly derived from the diet and supplied through C-1 metabolism by way of choline, betaine, methionine or folate, with involvement of riboflavin and vitamins B-6 and B-12 as cofactors. Mouse models have shown that epigenetic features, for example DNA methylation, can be altered by peri-conceptional nutritional interventions such as folate supplementation, thereby changing offspring phenotype. Evidence of early nutrient-induced epigenetic change in human subjects is scant, but it is known that during pregnancy C-1 metabolism has to cope with high fetal demands for folate and choline needed for neural tube closure and normal development. Retrospective studies investigating the effect of famine or season during pregnancy indicate that variation in early environmental exposure in utero leads to differences in DNA methylation of offspring. This may affect gene expression in the offspring. Further research is needed to examine the real impact of maternal nutrient availability on DNA methylation in the developing fetus.
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