期刊
PROCEEDINGS OF THE NUTRITION SOCIETY
卷 69, 期 3, 页码 286-289出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0029665110001722
关键词
Vitamin D; Regulatory T cells; Inflammatory bowel disease; Multiple sclerosis
资金
- NCCIH NIH HHS [R01 AT005378-02, R01 AT005378, AT005378] Funding Source: Medline
- NIDDK NIH HHS [DK070781, R01 DK070781, R01 DK070781-03] Funding Source: Medline
- NINDS NIH HHS [R01 NS067563, R01 NS067563-01A1] Funding Source: Medline
Vitamin D and the vitamin D receptor (VDR) have been shown to be important regulators of the immune system. In particular, vitamin D and VDR deficiency exacerbates experimental autoimmune diseases such as inflammatory bowel disease (IBD). IBD develops due to an immune-mediated attack by pathogenic T-cells that overproduce IL-17 and IFN-gamma and a few regulatory cells. VDR knockout mice have twice as many T-cells making IL-17 and IFN-gamma than wild-type mice. In addition, vitamin D and the VDR are required for normal numbers of regulatory T-cells (iNKT and CD8 alpha alpha) that have been shown to suppress experimental IBD. In the absence of vitamin D and the VDR, autoimmunity occurs in the gastrointestinal tract due to increased numbers of IL-17 and IFN-gamma secreting T-cells and a concomitant reduction in regulatory T-cells.
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