期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 39, 页码 E9145-E9152出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1805371115
关键词
epigenetics; Arabidopsis thaliana; DNA methylation; transgenerational inheritance; asexual reproduction
资金
- European Research Council (ERC) Marie Sklodowska-Curie Fellowship [751204-H2020-MSCA-IF-2016]
- ERC AdG IMMUNEMESIS Project
- Deutsche Forschungsgemeinschaft [SPP1529]
- Max Planck Society
- ERC AdG ROOTMICROBIOTA Project
- Cluster of Excellence on Plant Sciences
- Biotechnology and Biological Sciences Research Council [BB/L025892/1, BB/L003023/1, BB/N005279/1, BB/N00194X/1, BB/P02601X/1]
- BBSRC [BB/L003023/1, BB/N00194X/1, BB/L025892/1, BB/N005279/1, BB/P02601X/1] Funding Source: UKRI
Plants differ from animals in their capability to easily regenerate fertile adult individuals from terminally differentiated cells. This unique developmental plasticity is commonly observed in nature, where many species can reproduce asexually through the ectopic initiation of organogenic or embryogenic developmental programs. While organ-specific epigenetic marks are not passed on during sexual reproduction, the fate of epigenetic marks during asexual reproduction and the implications for clonal progeny remain unclear. Here we report that organ-specific epigenetic imprints in Arabidopsis thaliana can be partially maintained during asexual propagation from somatic cells in which a zygotic program is artificially induced. The altered marks are inherited even over multiple rounds of sexual reproduction, becoming fixed in hybrids and resulting in heritable molecular and physiological phenotypes that depend on the identity of the founder tissue. Consequently, clonal plants display distinct interactions with beneficial and pathogenic microorganisms. Our results demonstrate how novel phenotypic variation in plants can be unlocked through altered inheritance of epigenetic marks upon asexual propagation.
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