期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 40, 页码 10154-10159出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1803667115
关键词
hippocampus; connnectome; microstructure; MRI; neuroimaging
资金
- McGill Faculty of Medicine
- Jeanne Timmins Costello Fellowship
- Canadian League Against Epilepsy
- Canadian Institutes of Health Research (CIHR) [FDN-154298]
- Fonds de la Recherche du Quebec-Sante (FRQS)
- National Science and Engineering Research Council of Canada (NSERC Grant Discovery) [1304413]
- SickKids Foundation [NI17-039]
- Azrieli Center for Autism Research of the Montreal Neurological Institute
- FRQS (Chercheur Boursier)
- European Research Council [WANDERINGMINDS - ERC646927]
- 16 NIH Institutes and Centers [1U54MH091657]
- McDonnell Center for Systems Neuroscience at Washington University
The hippocampus plays key roles in cognition and affect and serves as a model system for structure/function studies in animals. So far, its complex anatomy has challenged investigations targeting its substructural organization in humans. State-of-the-art MRI offers the resolution and versatility to identify hippocampal subfields, assess its microstructure, and study topographical principles of its connectivity in vivo. We developed an approach to unfold the human hippocampus and examine spatial variations of intrinsic functional connectivity in a large cohort of healthy adults. In addition to mapping common and unique connections across subfields, we identified two main axes of subregional connectivity transitions. An anterior/posterior gradient followed long-axis landmarks and metaanalytical findings from task-based functional MRI, while a medial/lateral gradient followed hippocampal infolding and correlated with proxies of cortical myelin. Findings were consistent in an independent sample and highly stable across resting-state scans. Our results provide robust evidence for long-axis specialization in the resting human hippocampus and suggest an intriguing interplay between connectivity and microstructure.
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