期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 41, 页码 10239-10244出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1807347115
关键词
PLLA; hydrolysis; coronary heart disease; BVS; X-ray microdiffraction
资金
- DOE Office of Science [DE-AC02-06CH11357]
- Abbott Vascular
- Jacobs Institute for Molecular Engineering for Medicine
- National Heart, Lung, and Blood Institute of the National Institutes of Health [F31HL137308]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [F31HL137308] Funding Source: NIH RePORTER
Biodegradable polymers open the way to treatment of heart disease using transient implants (bioresorbable vascular scaffolds, BVSs) that overcome the most serious complication associated with permanent metal stents-late stent thrombosis. Here, we address the long-standing paradox that the clinically approved BVS maintains its radial strength even after 9 mo of hydrolysis, which induces a similar to 40% decrease in the poly L-lactide molecular weight (Mn). X-ray microdiffraction evidence of nonuniform hydrolysis in the scaffold reveals that regions subjected to tensile stress during crimping develop a microstructure that provides strength and resists hydrolysis. These beneficial morphological changes occur where they are needed most-where stress is localized when a radial load is placed on the scaffold. We hypothesize that the observed decrease in Mn reflects the majority of the material, which is undeformed during crimping. Thus, the global measures of degradation may be decoupled from the localized, degradation-resistant regions that confer the ability to support the artery for the first several months after implantation.
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