期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 6, 页码 2182-2187出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1318460111
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资金
- EU FP7 program AGRON-OMICS network [037704]
- National Science Foundation of China [31271438]
- Leverhulme [F00424R]
- BBSRC [BB/F018754/1]
- Biotechnology and Biological Sciences Research Council Grant [BB/J004405/1]
- Euporean Union Framework 7 Knowledge-Based Bio-Economy collaborative network 222883 'Meiosys
- BBSRC [BB/F018754/1, BB/J007633/1, BBS/E/W/10962A01B] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/0000A216, BB/F018754/1, BB/J007633/1, BBS/E/W/10962A01B] Funding Source: researchfish
The Arabidopsis cyclin-dependent kinase G (CDKG) gene defines a clade of cyclin-dependent protein kinases related to CDK10 and CDK11, as well as to the enigmatic Ph1-related kinases that are implicated in controlling homeologous chromosome pairing in wheat. Here we demonstrate that the CDKG1/CYCLINL complex is essential for synapsis and recombination during male meiosis. A transfer-DNA insertional mutation in the cdkg1 gene leads to a temperature-sensitive failure of meiosis in late Zygotene/Pachytene that is associated with defective formation of the synaptonemal complex, reduced bivalent formation and crossing over, and aneuploid gametes. An aphenotypic insertion in the cyclin L gene, a cognate cyclin for CDKG, strongly enhances the phenotype of cdkg1-1 mutants, indicating that this cdk-cyclin complex is essential for male meiosis. Since CYCLINL, CDKG, and their mammalian homologs have been previously shown to affect mRNA processing, particularly alternative splicing, our observations also suggest a mechanism to explain the widespread phenomenon of thermal sensitivity in male meiosis.
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