期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 9, 页码 3514-3519出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1320198111
关键词
liquid biopsy; blood cell biomarkers; cancer metastasis; cancer biomarker; cancer screening
资金
- Maryland Technology Development Corporation/Maryland Technology Transfer Commercialization Fund
- National Cancer Institute [R01-CA154624]
- Era of Hope Scholar Award from the Department of Defense [BC100675]
- Advancing a Healthier Wisconsin
- National Institutes of Health [CA90386, CA122985]
- Prostate Specialized Program of Research Excellence [CA90386]
- Susan G. Komen Foundation [KG100240]
Tumor-associated macrophages (TAMs) derived from primary tumors are believed to facilitate circulating tumor cell (CTC) seeding of distant metastases, but the mechanisms of these processes are poorly understood. Although many studies have focused on the migration of CTCs, less attention has been given to TAMs that, like CTCs, derive from tumor sites. Using precision microfilters under low-flow conditions, we isolated circulating cancer-associated macrophage-like cells (CAMLs) from the peripheral blood of patients with breast, pancreatic, or prostate cancer. CAMLs, which are not found in healthy individuals, were found to express epithelial, monocytic, and endothelial protein markers and were observed bound to CTCs in circulation. These data support the hypothesis that disseminated TAMs can be used as a biomarker of advanced disease and suggest that they have a participatory role in tumor cell migration.
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