期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 20, 页码 7456-7461出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1324118111
关键词
connectome; brain development; tractography; preterm birth
资金
- Medical Research Council
- Engineering and Physical Sciences Research Council
- National Institute for Health Research Comprehensive Biomedical Research Centre
- King's College London
- King's College Hospital NHS Foundation Trust
- Garfield Weston Foundation
- Action Medical Research [1772] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I000445/1] Funding Source: researchfish
- Medical Research Council [MR/J014311/1, MR/K006355/1] Funding Source: researchfish
- National Institute for Health Research [CL-2012-17-006, ACF-2006-21-028, RP-PG-0707-10154] Funding Source: researchfish
- EPSRC [EP/I000445/1] Funding Source: UKRI
- MRC [MR/K006355/1, MR/J014311/1] Funding Source: UKRI
Combining diffusion magnetic resonance imaging and network analysis in the adult human brain has identified a set of highly connected cortical hubs that form a rich club-a high-cost, high-capacity backbone thought to enable efficient network communication. Rich-club architecture appears to be a persistent feature of the mature mammalian brain, but it is not known when this structure emerges during human development. In this longitudinal study we chart the emergence of structural organization in mid to late gestation. We demonstrate that a rich club of interconnected cortical hubs is already present by 30 wk gestation. Subsequently, until the time of normal birth, the principal development is a proliferation of connections between core hubs and the rest of the brain. We also consider the impact of environmental factors on early network development, and compare term-born neonates to preterm infants at term-equivalent age. Though rich-club organization remains intact following premature birth, we reveal significant disruptions in both in cortical-subcortical connectivity and short-distance corticocortical connections. Rich club organization is present well before the normal time of birth and may provide the fundamental structural architecture for the subsequent emergence of complex neurological functions. Premature exposure to the extrauterine environment is associated with altered network architecture and reduced network capacity, which may in part account for the high prevalence of cognitive problems in preterm infants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据