期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 2, 页码 584-589出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1423136112
关键词
rapid eye movement sleep; acetylcholine; optogenetics; mesopontine tegmentum; mouse
资金
- NIH [DP1-OD003646, TR01-GM104948, T32-HL07901]
- Massachusetts General Hospital Executive Committee on Research Fellowship
- Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital
Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep.
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