期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 3, 页码 1049-1054出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1322229111
关键词
CD8 T cells; HLA types
资金
- University of Melbourne International Research Scholarship
- Consejo Nacional de Ciencia y Tecnologia Scholar
- Aboriginal and Torres Strait Islander Health Research scholarship
- Singapore Ministry of Education Academic Research Fund [MOE2011-T2-2-049]
- Agency for Science, Technology and Research, Singapore
- Ministry of Health, Singapore
- Australian National Health and Medical Research Council (NHMRC) [AI1008854, AI1042662]
- NHMRC [AI567122]
The absence of preexisting neutralizing antibodies specific for the novel A (H7N9) influenza virus indicates a lack of prior human exposure. As influenza A virus-specific CD8(+) T lymphocytes (CTLs) can be broadly cross-reactive, we tested whether immunogenic peptides derived from H7N9 might be recognized by memory CTLs established following infection with other influenza strains. Probing across multiple ethnicities, we identified 32 conserved epitopes derived from the nucleoprotein (NP) and matrix-1 (M1) proteins. These NP and M1 peptides are presented by HLAs prevalent in 16-57% of individuals. Remarkably, some HLA alleles (A*0201, A*0301, B*5701, B*1801, and B*0801) elicit robust CTL responses against any human influenza A virus, including H7N9, whereas ethnicities where HLA-A*0101, A*6801, B*1501, and A*2402 are prominent, show limited CTL response profiles. By this criterion, some groups, especially the Alaskan and Australian Indigenous peoples, would be particularly vulnerable to H7N9 infection. This dissection of CTL-mediated immunity to H7N9 thus suggests strategies for both vaccine delivery and development.
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