期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 48, 页码 16990-16994出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1415861111
关键词
evolutionary cell biology; cell biology; adaptive evolution; random genetic drift; cellular evolution
资金
- Workshop on Evolutionary Cell Biology [MCB-1228570]
- National Science Foundation [IOS-1051962, MCB-1050161, MCB1051985, MCB-1244593]
- National Institutes of Health [R01-GM036827, R01-105783, R01-GM74108, R01-AI49301]
- US Army Research Office Grant [W911NF-09-1-0444]
- Fundacao para a Cincia e Tecnologia Grant [PTDC/EBBBIO/119006/2010]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1051962] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1244593, 1228570] Funding Source: National Science Foundation
- Fundação para a Ciência e a Tecnologia [PTDC/EBB-BIO/119006/2010] Funding Source: FCT
All aspects of biological diversification ultimately trace to evolutionary modifications at the cellular level. This central role of cells frames the basic questions as to how cells work and how cells come to be the way they are. Although these two lines of inquiry lie respectively within the traditional provenance of cell biology and evolutionary biology, a comprehensive synthesis of evolutionary and cell-biological thinking is lacking. We define evolutionary cell biology as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics. The key goals are to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective. The full development of this interdisciplinary field has the potential to solve numerous problems in diverse areas of biology, including the degree to which selection, effectively neutral processes, historical contingencies, and/or constraints at the chemical and biophysical levels dictate patterns of variation for intracellular features. These problems can now be examined at both the within-and among-species levels, with single-cell methodologies even allowing quantification of variation within genotypes. Some results from this emerging field have already had a substantial impact on cell biology, and future findings will significantly influence applications in agriculture, medicine, environmental science, and synthetic biology.
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