期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 44, 页码 15614-15621出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1413550111
关键词
HIV; vaccine; antibody persistence; AIDS; T cell
资金
- Bill and Melinda Gates Foundation [OPP1017606, OPP1033109]
- NIH [RC2CA148473, R01AI087181]
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- Bill and Melinda Gates Foundation [OPP1033109, OPP1017606] Funding Source: Bill and Melinda Gates Foundation
The quest for a prophylactic AIDS vaccine is ongoing, but it is now clear that the successful vaccine must elicit protective antibody responses. Accordingly, intense efforts are underway to identify immunogens that elicit these responses. Regardless of the mechanism of antibody-mediated protection, be it neutralization, Fc-mediated effector function, or both, antibody persistence and appropriate T-cell help are significant problems confronting the development of a successful AIDS vaccine. Here, we discuss the evidence illustrating the poor persistence of antibody responses to Env, the envelope glycoprotein of HIV-1, and the related problem of CD4(+) T-cell responses that compromise vaccine efficacy by creating excess cellular targets of HIV-1 infection. Finally, we propose solutions to both problems that are applicable to all Env-based AIDS vaccines regardless of the mechanism of antibody-mediated protection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据