期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 1, 页码 E39-E48出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1415107111
关键词
gammadelta T cell; interleukin-4; autoimmunity; immunoglobulin; tolerance
资金
- NIH [R21 AI095765, R21 AI097962, R01 EY021199]
- Grants-in-Aid for Scientific Research [25460589, 25111504] Funding Source: KAKEN
- Biotechnology and Biological Sciences Research Council [BBS/E/F/00044446] Funding Source: researchfish
- BBSRC [BBS/E/F/00044446] Funding Source: UKRI
gamma delta T cells can influence specific antibody responses. Here, we report that mice deficient in individual. gamma delta T- cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of alpha beta T cells. One strain with a partial.d deficiency that increases IgE antibodies also displayed increases in IL- 4- producing T cells (both residual.d T cells and aa T cells) and in systemic IL- 4 levels. Its B cells expressed IL- 4- regulated inhibitory receptors (CD5, CD22, and CD32) at diminished levels, whereas IL- 4- inducible IL- 4 receptor a and MHCII were increased. They also showed signs of activation and spontaneously formed germinal centers. These mice displayed IgE- dependent features found in hyper- IgE syndrome and developed antichromatin, antinuclear, and anticytoplasmic autoantibodies. In contrast, mice deficient in all.d T cells had nearly unchanged Ig levels and did not develop autoantibodies. Removing IL- 4 abrogated the increases in IgE, antichromatin antibodies, and autoantibodies in the partially gamma deficient mice. . Our data suggest that gamma delta T cells, controlled by their own cross- talk, affect IL- 4 production, B- cell activation, and B- cell tolerance.
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