期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 45, 页码 15952-15957出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1414678111
关键词
IRES elements; translation regulation; RNA viruses; hepatitis C virus
资金
- Graduate Assistance in Areas of National Need fellowship from the US Department of Education
- University of California, San Diego, Academic Senate [RM069B]
- National Institutes of Health [OD011957]
- Chemistry Research Instrumentation and Facilities Program [CHE-0741968]
An internal ribosome entry site (IRES) initiates protein synthesis in RNA viruses, including the hepatitis C virus (HCV). We have discovered ligand-responsive conformational switches in viral IRES elements. Modular RNA motifs of greatly distinct sequence and local secondary structure have been found to serve as functionally conserved switches involved in viral IRES-driven translation and may be captured by identical cognate ligands. The RNA motifs described here constitute a new paradigm for ligand-captured switches that differ from metabolite-sensing riboswitches with regard to their small size, as well as the intrinsic stability and structural definition of the constitutive conformational states. These viral RNA modules represent the simplest form of ligand-responsive mechanical switches in nucleic acids.
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