期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 14, 页码 5307-5312出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1322292111
关键词
intravital imaging HSV-1 infection; Langerhans cells; Brownian motion
资金
- National Health and Medical Research Council of Australia
- Australian Research Council
- UK Biotechnology and Biological Sciences Research Council Institute Strategic Programme grant
- European Research Council [280307:Epithelial_Immunol]
- BBSRC [BBS/E/B/000C0407, BBS/E/B/0000H119, BBS/E/B/0000S042] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0407, BBS/E/B/0000H119, BBS/E/B/0000S042] Funding Source: researchfish
Barrier tissues such as the skin contain various populations of immune cells that contribute to protection from infections. These include recently identified tissue-resident memory T cells (T-RM). In the skin, these memory CD8(+) T cells reside in the epidermis after being recruited to this site by infection or inflammation. In this study, we demonstrate prolonged persistence of epidermal T-RM preferentially at the site of prior infection despite sustained migration. Computational simulation of T-RM migration within the skin over long periods revealed that the slow rate of random migration effectively constrains these memory cells within the region of skin in which they form. Notably, formation of T-RM involved a concomitant local reduction in dendritic epidermal gamma delta T-cell numbers in the epidermis, indicating that these populations persist in mutual exclusion and may compete for local survival signals. Accordingly, we show that expression of the aryl hydrocarbon receptor, a transcription factor important for dendritic epidermal gamma delta T-cell maintenance in skin, also contributes to the persistence of skin T-RM. Together, these data suggest that skin tissue-resident memory T cells persist within a tightly regulated epidermal T-cell niche.
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