期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 4, 页码 1310-1315出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1318602111
关键词
nanoparticle characterization; NEMS; microfluidics; mechanical oscillators
资金
- Institute for Collaborative Biotechnologies [W911NF-09-D-0001]
- US Army Research Office Center for Integration of Medicine and Innovative Technology [09-440]
- National Science Foundation [1129359]
- Koch Institute Support (core) [P30-CA14051]
- National Cancer Institute
- Directorate For Geosciences
- Division Of Ocean Sciences [1129359] Funding Source: National Science Foundation
Physical characterization of nanoparticles is required for a wide range of applications. Nanomechanical resonators can quantify the mass of individual particles with detection limits down to a single atom in vacuum. However, applications are limited because performance is severely degraded in solution. Suspended micro- and nanochannel resonators have opened up the possibility of achieving vacuum-level precision for samples in the aqueous environment and a noise equivalent mass resolution of 27 attograms in 1-kHz bandwidth was previously achieved by Lee et al. [(2010) Nano Lett 10(7): 2537-2542]. Here, we report on a series of advancements that have improved the resolution by more than 30-fold, to 0.85 attograms in the same bandwidth, approaching the thermomechanical noise limit and enabling precise quantification of particles down to 10 nm with a throughput of more than 18,000 particles per hour. We demonstrate the potential of this capability by comparing the mass distributions of exosomes produced by different cell types and by characterizing the yield of self-assembled DNA nanoparticle structures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据