期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 39, 页码 14265-14270出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1411216111
关键词
hippocampus; AMPA receptor trafficking
资金
- Netherlands Organization for Scientific Research Grants [863.13.021, 817.02.017, 024.001.003]
- Federation of European Neuroscience Societies/Network of European Neuroscience Schools
- Centre National de la Recherche Scientifique
- France BioImaging
- Conseil Regional d'Aquitaine
- Agence National de la Recherche [ANR-JC08-329238]
The rodent adrenal hormone corticosterone (CORT) reaches the brain in hourly ultradian pulses, with a steep rise in amplitude before awakening. The impact of a single CORT pulse on glutamatergic transmission is well documented, but it remains poorly understood how consecutive pulses impact on glutamate receptor trafficking and synaptic plasticity. By using high-resolution imaging and electrophysiological approaches, we report that a single pulse of CORT to hippocampal networks causes synaptic enrichment of glutamate receptors and increased responses to spontaneously released glutamatergic vesicles, collectively abrogating the ability to subsequently induce synaptic long-term potentiation. Strikingly, a second pulse of CORT one hour after the first-mimicking ultradian pulses-completely normalizes all aspects of glutamate transmission investigated, restoring the plastic range of the synapse. The effect of the second pulse is precisely timed and depends on a nongenomic glucocorticoid receptor-dependent pathway. This normalizing effect through a sequence of CORT pulses-as seen around awakening-may ensure that hippocampal glutamatergic synapses remain fully responsive and able to encode new stress-related information when daily activities start.
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