期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 11, 页码 4374-4379出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1217505110
关键词
Purkinje cells; dendrites
资金
- Fondazione Istituto di Ricerca e Cura a Carattere Scientific Policlinico San Matteo-Ricerca Corrente
- Ministero dell'Universita e della Ricerca-Progetti di Rilevante Interesse Nazionale
- Compagnia di San Paolo [Gabagen Project]
- Ministero dell'Universita e della Ricerca Fondo per l'Incentivazione della Ricerca di Base Research Grant [RBFR10A01S]
Neurons in mammals do not undergo replicative aging, and, in absence of pathologic conditions, their lifespan is limited only by the maximum lifespan of the organism. Whether neuronal lifespan is determined by the strain-specific lifetime or can be extended beyond this limit is unknown. Here, we transplanted embryonic mouse cerebellar precursors into the developing brain of the longer-living Wistar rats. The donor cells integrated into the rat cerebellum developing into mature neurons while retaining mouse-specific morphometric traits. In their new environment, the grafted mouse neurons did not die at or before the maximum lifespan of their strain of origin but survived as long as 36 mo, doubling the average lifespan of the donor mice. Thus, the lifespan of neurons is not limited by the maximum lifespan of the donor organism, but continues when transplanted in a longer-living host.
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