期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 11, 页码 4345-4350出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1300321110
关键词
bioclogging; biofouling; porous media
资金
- Howard Hughes Medical Institute
- National Institutes of Health [5R01GM065859]
- National Science Foundation (NSF) [MCB-0343821]
- NSF [MCB-1119232]
- Human Frontier Science Program
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1119232, 0948112] Funding Source: National Science Foundation
Biofilms are antibiotic-resistant, sessile bacterial communities that occupy most moist surfaces on Earth and cause chronic and medical device-associated infections. Despite their importance, basic information about biofilm dynamics in common ecological environments is lacking. Here, we demonstrate that flow through soil-like porous materials, industrial filters, and medical stents dramatically modifies the morphology of Pseudomonas aeruginosa biofilms to form 3D streamers, which, over time, bridge the spaces between obstacles and corners in nonuniform environments. We discovered that accumulation of surface-attached biofilm has little effect on flow through such environments, whereas biofilm streamers cause sudden and rapid clogging. We demonstrate that flow-induced shedding of extracellular matrix from surface-attached biofilms generates a sievelike network that captures cells and other biomass, which add to the existing network, causing exponentially fast clogging independent of growth. These results suggest that biofilm streamers are ubiquitous in nature and strongly affect flow through porous materials in environmental, industrial, and medical systems.
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