期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 31, 页码 12541-12544出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1307122110
关键词
droplet control; elasticity; soft matter; wetting; mechanosensing
资金
- Yale University
- Swedish Research Council
- National Science Foundation [DBI-0619674]
- Yale Institute for Nanoscience and Quantum Engineering
- Creative Research Initiatives (Functional X-ray Imaging) of the Ministry of Education, Science and Technology/National Research Foundation of Korea
- DOE [DE-AC02-06CH11357]
Numerous cell types have shown a remarkable ability to detect and move along gradients in stiffness of an underlying substrate-a process known as durotaxis. The mechanisms underlying durotaxis are still unresolved, but generally believed to involve active sensing and locomotion. Here, we show that simple liquid droplets also undergo durotaxis. By modulating substrate stiffness, we obtain fine control of droplet position on soft, flat substrates. Unlike other control mechanisms, droplet durotaxis works without imposing chemical, thermal, electrical, or topographical gradients. We show that droplet durotaxis can be used to create large-scale droplet patterns and is potentially useful for many applications, such as microfluidics, thermal control, and microfabrication.
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