期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 9, 页码 3555-3560出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1218510110
关键词
RNAseq; microarray; Nxph4; Tpd52l1; interstitial white matter cells
资金
- Medical Research Council [G00900901, G0700377]
- Wellcome Trust
- Lincoln College, Oxford
- National Institute for Health Research Academic Clinical Fellowship
- Marshall-National Institutes of Health-Oxford Scholarship
- John Fell Fund
- Wellcome Trust Integrative Physiology Initiative in Ion Channels and Diseases of Electrically Excitable Cells
- European Union [241995]
- BBSRC [BB/I021833/1] Funding Source: UKRI
- MRC [MR/L001578/1, MC_UP_A320_1004, G0700377, MR/K006355/1, MC_UU_12021/4, MC_U120097112] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I021833/1] Funding Source: researchfish
- Medical Research Council [MR/K006355/1, MC_UP_A320_1004, MC_UU_12021/4, MC_U120097112, G0700377, MR/L001578/1, 1577487] Funding Source: researchfish
- National Institute for Health Research [ACF-2010-21-034] Funding Source: researchfish
The subplate zone is a highly dynamic transient sector of the developing cerebral cortex that contains some of the earliest generated neurons and the first functional synapses of the cerebral cortex. Subplate cells have important functions in early establishment and maturation of thalamocortical connections, as well as in the development of inhibitory cortical circuits in sensory areas. So far no role has been identified for cells in the subplate in the mature brain and disease association of the subplate-specific genes has not been analyzed systematically. Here we present gene expression evidence for distinct roles of the mouse subplate across development as well as unique molecular markers to extend the repertoire of subplate labels. Performing systematic comparisons between different ages (embryonic days 15 and 18, postnatal day 8, and adult), we reveal the dynamic and constant features of the markers labeling subplate cells during embryonic and early postnatal development and in the adult. This can be visualized using the online database of subplate gene expression at https://molnar.dpag.ox.ac.uk/subplate/. We also identify embryonic similarities in gene expression between the ventricular zones, intermediate zone, and subplate, and distinct postnatal similarities between subplate, layer 5, and layers 2/3. The genes expressed in a subplate-specific manner at some point during development show a statistically significant enrichment for association with autism spectrum disorders and schizophrenia. Our report emphasizes the importance of the study of transient features of the developing brain to better understand neurodevelopmental disorders.
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